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Thomas C. Irving, Ph.D.

Thomas C. Irving
Professor of Biology and Physics
Executive Associate Chair, Biology Division, BCS Department
Director of Biophysics Collaborative Access Team (BioCAT)
Professor of Biomedical Engineering

Office: 

182B Life Sciences Building

Phone: 

312.567.3489

Fax: 

312.567.3494

Email: 

Education 

B.S. University of Guelph
M.S. University of Guelph
Ph.D. University of Guelph

Expertise 

Biophysics of muscle contraction, non-crystalline x-ray diffraction, synchrotron radiation instrumentation

Research 

  • Operate a Biotechnology Research Center at the Advanced Photon Source for non-crystalline diffraction scattering and x-ray spectroscopy of biological molecules, collaboration with NIH/NCRR
  • Deduce the structural and functional l roles of My-BP-C in cardiac muscle contraction, collaboration with University of Wisconsin/NIH
  • Deduce the structural and functional and structural roles of titin in muscle contraction, collaboration with University of Arizona/NIH

Awards 

  • Ontario Scholar (1974)
  • I.O.D.E. Capt. Frederick Bond Memorial University Entrance Scholarship
  • Ontario Graduate Scholarship (1983-84)(1985-86)
  • Canadian Heart Foundation Post-doctoral Fellowship (1989 - 1991)
  • IITRI fellow (1998- 2000)
  • Sigma Xi / IIT Award for Excellence in University Research (senior division) 2007

Professional Society Memberships 

  • Biophysical Society
  • American Crystallographic Association
  • Sigma Xi

Publications 

1. Irving, T.C. 1998. A bright future for non-crystalline diffraction using synchrotron radiation. Nature Structural Biology, 5:Synchrotron Supplement, August 1998.

2. Colson, B.A., Bekyarova, T., Irving, T.C., and Moss, R.L (2008). Radial displacement of myosin cross-bridges in mouse myocardium due to ablation of myosin binding protein-C. J. Mol. Biol. 367, 36-41

3. Bekyarova T.I., Reedy M.C., Baumann B.A., Tregear R.T., Ward A., Krzic U., Prince K.M., Perz-Edwards R.J., Reconditi M., Gore D., Irving T.C., Reedy M.K. (2008).  Reverse actin sliding triggers strong myosin binding that moves tropomyosin. Proc Natl Acad Sci U S A.105:10372-7.

4. Michael Dickinson, Gerrie Farman, Mark Frye, Tanya Bekyarova, David Gore, David Maughan and Thomas C. Irving. Molecular Dynamics of Cyclically Contracting Insect Flight Muscle. Nature 433:330-333R.

5. Fischetti, S. Stepanov, G. Rosenbaum, R. Barrea, D. Gore, R. Heurich, E. Kondrashkina, S. Wang, Ke Zhang, T.C. Irving and G.B. Bunker. The BioCAT Undulator Beamline 18ID: A Facility for Biological Non-Crystalline Diffraction and X-ray Absorption Spectroscopy at the Advanced Photon Source. Journal of Synchrotron Radiation,11:399-405.

6. Tsuruta H, Irving TC. (2008) Experimental approaches for solution X-ray scattering and fiber diffraction. Curr Opin Struct Biol. 18(5):601-8